METHOD OF SYNTHESIS OF IMIDAZOLE DERIVATIVE Russian patent published in 1995 - IPC

Abstract RU 2026293 C1

FIELD: organic chemistry. SUBSTANCE: product: compound of the formula (I) R1 where C1-C6 - H, R2-alkyl; C1-C4 - alkyl substituted with R3-R6-alkoxy-group; every of C1-C6 - are independent - H, halide, C1-C6-alkyl, C1-C6-alkoxy-group, fluoro-substituted C1-C6-alkyl or fluoro-substituted -alkoxy-group. Reagent 1: compound of the formula (II) where X - splitting off group. Reagent 2: 2-mercaptoimidazole. Reagent 3: compound of the formula (III) . Reaction conditions: oxidation of reagents indicated above. Synthesized compounds are used in medicine as drugs showing enhanced antiulcer activity and lowered toxicity. EFFECT: improved method of synthesis.

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RU 2 026 293 C1

Authors

Susumu Okabe[Jp]

Mitsuo Masaki[Jp]

Tomio Jamakava[Jp]

Khitosi Matsukura[Jp]

Jutaka Nomura[Jp]

Dates

1995-01-09Published

1990-09-09Filed