METHOD OF SYNTHESIS OF N-ALKYLDERIVATIVE ANTIBIOTICS OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS Russian patent published in 1995 - IPC

FIELD: organic chemistry. SUBSTANCE: product: N-alkylderivatives of antibiotics or their pharmaceutical salts of the formula (I) where R₁ - H, CH₃ (in this case D-alanyl is formed); R₂ - H, β-D-xylosyl; Y - where R₃, R₄, R₅ - C₁-C₅-alkyl, X - anion. The yield is 80%, empirical formula is C₄₂H₄₂N₂O₁₈Cl, Y-N(CH₃)₃Cl. Reagent 1: corresponding substituted (I) where Y - NR₇R₈; R₇ and R₈ - H or C₁-C₅-alkyl. Reagent 2: C₁-C₅ -alkylhalogenide. Reaction conditions: at the room temperature in the presence of sodium hydrocarbonate. Synthesized compounds are used as antifungal agents. EFFECT: improved method of synthesis. 2 tbl