CIS-N-IMINOMETHYL-3,4-DISUBSTITUTED-β-LACTAMS AND METHODS OF PREPARING CIS-3,4-DISUBSTITUTED-β-LACTAMS, AND USE THEREOF Russian patent published in 1999 - IPC

FIELD: medicine. SUBSTANCE: cis-N- imonomerthyl-3,4-disubstituted-2-azethidinones are prepared and used for preparing N-acyl-2-azetidinones which are intermediate compounds in semisynthesis of taxol and its derivatives having anticancer activity. Cis-N-iminomethyl-3,4-disubstituted β lactams of formula : wherein R¹ is selected from group consisting of (C₁-C₆) alkyl, (C₁-C₆) alkyl substituted by halogen; phenyl, naphthyl, alkylphenyl or carbohydrate derivative containing pyranosyl group; X is selected from group consisting of phenyl and naphthyl substituted by 1-3 identical or different substituents from (C₁-C₃) alkyl, (C₁-C₃) alkoxy, hydroxy, trifluoromethyl and halogen; furyl, and thienyl. EFFECT: more efficient preparation methods. 33 cl, 25 ex