FIELD: organic chemistry. SUBSTANCE: new method of synthesis of novel early not described derivatives of 5-chloro-2-amino-substituted benzhydrylureas. Reagent 1: urea. Reagent 2: 5-chloro-2-amino-substituted benzhydrols. Reaction conditions: reaction is carried out in concentrated sulfuric acid at the ratio of reagent 1 and 2 and sulfuric acid = (8-9):1:(4-4.3). Yield is 70-80%. Synthesized compounds were used for medicinal preparations preparing. EFFECT: improved method of synthesis. 2 tbl
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Authors
Dates
1995-03-10—Published
1990-10-22—Filed