OPTIC ISOMERS OF (+) AND (-)-BENZHYDRYLUREAS AND (+) AND (-)-1-[(3-CHLOROPHENYL)-PHENYL-METHYL]UREA, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD OF THEREOF OBTAINING Russian patent published in 2015 - IPC C07C275/18 C07C273/02 A61K31/17 A61P25/08 

Abstract RU 2537361 C1

FIELD: chemistry.

SUBSTANCE: invention relates to optic isomers of (+)- and (-)-1-[(3- chlorophenyl)-phenyl-methyl]urea, to based on them pharmaceutical composition, possessing anti- convulsive activity, as well as to method of obtaining said isomers. Method is realized by interaction of racemic mixture of respective benzhydrylamine with tartaric acids in organic solvent with obtaining diastereomers of benzhydrylamine tartrates, which further react with cyanates of alkali metals in water solution with obtaining isomers (+)- and (-)-1-[(3-chlorophenyl)-phenyl-methyl]urea.

EFFECT: optic isomers, possessing different strength of therapeutic activity and method of their obtaining.

10 cl, 1 dwg, 4 tbl, 2 ex

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RU 2 537 361 C1

Authors

Khudolej Vladimir Nikolaevich

Doroshenko Aleksandr Sergeevich

Filimonov Viktor Dmitrievich

Shtrykova Viktorija Viktorovna

Kuksenok Vera Jur'Evna

Dates

2015-01-10Published

2013-07-18Filed