FIELD: organic chemistry. SUBSTANCE: product: new chemical substance - halogen-substituted N-benzhydryl-N'-(trifluoroacetyl)-ureas of the formula: R-N′ where R - 2-F (I), 3-F (II), 4-F (III), 4-Cl (IV). Empirical formula of (I) is C6H4-CH(NHCONHCO-CF3)-C6H5,, m. p. is 127-128 C; empirical formula of (II) is C16H12F4N2O2,, m. p. is 133-134 C; empirical formula of (III) is C16H12F4N2O2,, m. p. is 103-105 C; empirical formula of (IV) is C16H12F4N2O2,, m. p. is 115-116 C. Synthesized compounds show antispasmodic activity and can be used in medicine. EFFECT: new compounds indicated above, improved method of synthesis. 4 tbl
Title | Year | Author | Number |
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N,N-DI- (BENZHYDRYL) -N-(TRIFLUOROACETYL)- UREAS SHOWING ANTICONVULSANT AND ENZYME-INDUCING ACTIVITY | 1991 |
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RU2070039C1 |
N-BENZHYDRYL-N'-(TRIFLUOROACETYL)-UREA SHOWING ANTICONVULSIVE ACTIVITY, AND A METHOD OF ITS SYNTHESIS | 1991 |
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MALONATES OF N-AMINOACYL DERIVATIVES OF N-SUBSTITUTED UREAS HAVING ANTISPASMODIC EFFECT | 0 |
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N-CYCLOZIDES OF BENZYHYDRYLURENA EXHIBITING ANTISPASMODIC ACTIVITY | 0 |
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Authors
Dates
1996-08-27—Published
1991-01-03—Filed