PROCESS FOR PREPARING (3-SUBSTITUTED AMINO) PROPIONYLOXY- 7-DIACETYLFORSCOLINE: DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF Russian patent published in 1995 - IPC

FIELD: medicine. SUBSTANCE: the product includes 6-beta-3(substituted aminospropionyloxy-7-diacetylforscoline derivatives of the formula 1 in which R₁ and R₂ are C₁-C₆-alkyl, or together with the nitrogen atom to which they are attached, form a piperizine, piperidine or morpholine ring unsubstituted or substituted with C₁-C₆-alkyl, or pharmaceutically acceptable salts thereof. The structure of the formula I. Reagent 1:7-diacethyl forscoline. Reagent 2: 3-halopropionyl halide. Process conditions: in the presence of an organic base followed by treatment of the resulting 6-beta-(3-halopropionyloxy) derivative with an amine of the formula HN(R₁)(R₂) in which R₁ and R₂ are as defined above and optionally by conversion thereof to pharmaceutically acceptable salts thereof. EFFECT: improved properties of the title compounds. 2 cl