IMIDAZOLONE DERIVATIVES, METHOD FOR PREPARING, AND BIOLOGICAL USE Russian patent published in 2013 - IPC C07D405/06 C07D405/14 C07D233/96 C07D401/06 C07D403/06 A61K31/4166 A61K31/4178 A61P25/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention refers to new imidazolone derivatives used as drugs being kinase inhibitors, described by formula (I), wherein; R₁ represents a C1-C3 alkyl radical or a hydrogen atom, and/or an aryl radical, Ar₁ is specified in or , R represents the group R₂-S-, R₂ is thereby specified in the radicals like T₁-(CH₂)_n, wherein n=0, 1, 2 or 3, and T₁ represents a metal, vinyl, alkyl, alkynyl, nitrile, C3- or C4-cycloalkyl radical, hal, Z-O, Z-CO, wherein Z represents C1-C3 alkyl or hal, hal represents F, Cl, Br or I, or the group CCl₃, or the group R₃-NH-, R₃ is thereby specified in the radicals like T₂-(CH₂)_n, wherein n=0, 1 or 2, and T₂ represents a metal, vinyl radical, Z-O, Z-CONH-, -CH-(OZ)₂, ZCO, wherein Z represents H or C1-C4 linear or branched alkyl, NH₂, C3-cycloalkyl, aryl, substituted aryl, or R₃ represents H, or the group R₄-CONH-, R₄ is thereby specified in C3-C5 branched alkyl, or Ar₂ ^- or Ar₂-3-, Ar₂ is specified in a phenyl radical, substituted phenyl or benzodioxolyl; and have IC₅₀ less than 5 mcM.

EFFECT: invention also refers to pharmaceutical compositions based on the compounds of formula I for treating neurodegenerative disorders and to using these compounds as DYRKIA inhibitors.

11 cl, 2 tbl, 8 ex