PROCESS FOR PREPARING 6-(3-DIMETHYLAMINOPROPIONYL FORSCOLINE) Russian patent published in 1995 - IPC

Abstract RU 2034841 C1

FIELD: medicine. SUBSTANCE: the product is 6-(3-dimethylaminopropionyl) forscoline of the formula 1 in which ac is acetyl. Reagent 1: 7-diacetyl-6-(3- dimethylaminopropionyl) forscoline. Reagent 2: acetic anhydride. Reagent 3: amine HN(R1)(R2) wherein R1-H or C1-C6-- alkyl; R2 is C1-C6-alkyl, preferably dimethylamine in an amount of 0.1-2.0 equivalents with respect to the resulting compound at the 1st stage of 1-acetyl-6-(3- dimethylaminopropionyl) forscoline is a solvent, preferably is methanol or ester. The yield is 88-91% with respect to 7-deacetyl-6-(3-dimethylaminopropionyl) forscoline of the formula 1. EFFECT: improved preparation process. 6 cl

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RU 2 034 841 C1

Authors

Akikhiro Masiba[Jp]

Jutaka Ogava[Jp]

Dates

1995-05-10Published

1991-10-31Filed