DERIVATIVES OF [([2- (AMINO -3,4-DIOXO -1-CYCLOBUTENE -1-YL)AMINO]ALKYL)] ACIDS Russian patent published in 1995 - IPC

FIELD: organic chemistry. SUBSTANCE: product of the formula (I) where R₁ hydrogen, C₁-C₆-alkyl or phenylalkyl with C₇-C₁₂; R₂ hydrogen, C₁-C₆-alkyl, C₂-C₆-alkenyl or phenylalkyl with C₇-C₁₂ or R₁ and R₂ together a group CH₂-CH₂-(CH₂)-CR₆R₇-CH₂ or -(CH₂)-CR₈R₉-CR₁₀R₁₁-CH₂- in which R₆, R₈, R₁₀ independently each of other hydrogen, C₁-C₆-alkyl or hydroxyl; R₇, R₉, R₁₁ independently each of other hydrogen or C₁-C₆-alkyl; A C₁-C₆-alkylene or C₁-C₆-alkenylene; X a group -C(O)OR₃ at R₃ hydrogen, C₁-C₆-alkyl or P(O)(OR₄)(OR₅) at R₄, R₅ independently each of other hydrogen, C₁-C₆-alkyl, 3,5-dioxo -1,2,4-oxadiazolidine-2-yl or 5-tetrazolyl, or their pharmaceutically acceptable salts. Reagent 1: compounds of the formula (II) where R₁ as indicated above, R₁₂ alkoxy, aralkoxy-substituted group containing C₁-C₅ or C₇-C_12/ . Reagent 2: compound of the formula HNR₂-A-X where R₂, A and X as indicated above. Reaction conditions: in the medium of solvent, at the room temperature or at heating. Synthesized compounds were used as anticonvulsive and neuroprotective agents at excessive release of exciting amino acids. EFFECT: improved method of synthesis. 1 tbl