C-22 STABILIZED DERIVATIVES OF RAPAMYCIN, METHOD OF IMMUNO- -SUPPRESSION INDUCING, METHOD OF TREATMENT AND PROPHYLAXIS OF TRANSPLANT REJECTION OR HOMOLOGOUS DISEASE, METHOD OF TREATMENT OR PROPHYLAXIS OF HYPERPROLIFERATIVE VASCULAR DISORDER Russian patent published in 2000 - IPC

FIELD: organic chemistry, medicine. SUBSTANCE: invention describes the novel compounds of the general formula (Ia) and (Ib) where R¹ means C₁-C₆-alkyl; R² is hydrogen atom, SiEt₃ or radical of the formula C(=O)-(CH₂)_yNR²¹R²² where j means the whole number 1-3; R²¹ and R²² mean C₁-C₃-alkyl; R³ is hydrogen atom or SiEt₃; R⁴ is hydrogen atom or SiEt₃, or their proline analogs, or their pharmaceutically acceptable salts. Proposed compounds are useful for induction of immunosuppression and treatment of transplant rejection, homologous disease, autoimmune and inflammatory sicknesses, solid tumors, fungal infections, leukosis, lymphomas, differentiated T-cells and hyperproliferative vascular disorders. Invention describes also method of induction of immunosuppression, treatment or prophylaxis of transplant rejection or homologous disease, method of treatment or prophylaxis of hyperproliferative vascular disorders. EFFECT: new compounds indicated above, valuable medicinal properties. 22 cl, 1 tbl, 7 ex