FIELD: organic chemistry. SUBSTANCE: product: derivatives of spiro-[isoquinoline-4-(1H)-3-pyrrolidine]-1,2',3,5'-(2H)-tetr- -one synthesized by interaction of 1,2,3,4-tetrahydro-1,3-dioxo-4-isoquinoline acetic acid esters with hydrazine hydrate. Synthesized compounds show pharmaceutical properties that can be used for prevention or treatment of diabetes mellitus-related complications. EFFECT: improved method of synthesis, enhanced effectiveness of compounds. 9 cl, 1 tbl
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