PROCESS FOR PREPARING COLLAGEN SPONGE Russian patent published in 1995 - IPC

FIELD: preparation of materials for medical purposes. SUBSTANCE: washing and grinding of collagen-containing stock of cattle skins; alkali-salt treatment of the ground stock; wetting in an aqueous 1 M acetic acid solution for 24 hours with a liquid coefficient of 2; washing the whole with water to a pH of 2.5-4; defibrillization in an aqueous medium, precipitation of the collagen at a pH of 5.5 and squeezing out the fibrous mass. A homogeneous collagen paste with a pH of 4.2-4.5 is prepared by homogenizing the squeezed-out fibrous mass in an aqueous 0.5-0.7% sodium hydroxide solution with a collagen content of 3% in the paste based on dry matter and subsequently adding acetic acid to a pH OF 4.2-4.5, introducing glutaric aldehyde cross-linking agent, cryostructurizing the collagen paste in the from of a layer at a temperature between minus 20 to minus 40 C, freezing it out and drying the whole to obtain a collagen sponge. EFFECT: more efficient process. 1 tbl