METHOD FOR ESTIMATING IMMUNIZATION EFFECTIVENESS IN THE CASE OF Q FEVER Russian patent published in 1995 - IPC

FIELD: medicine; immunology. SUBSTANCE: method involves preparatively infecting both immunized and not immunized animals, for example, guinea pigs, with Bernette coxiellae 28 days in advance. Peripheral blood smears are to be prepared before living Bernette coxiellae administration and 2-3 days later on. Bernette coxiellae are dried to determine the mean cytochrome coefficient from a formula shown in the patent application using neutrophil granulocyte staining intensity data obtained under microscopic examination. Immunization is considered to be successful, if the case value is lowered in comparison to the initial one not more than by 15% In this case the cation protein mean cytochrome coefficient in the control group of animals is to be lower than that in the initial group not less than by 25% EFFECT: enhanced accuracy and sensitivity in estimating immunization success level. 1 tbl