1,3-DIOXANE DERIVATIVES OF ALKENOIC ACID OR THEIR PHARMACEUTICALLY ACCEPTABLE SALT Russian patent published in 1995 - IPC

Abstract RU 2040525 C1

FIELD: organic chemistry. SUBSTANCE: product: 1,3-dioxane derivatives of alkenoic acid of the formula (I) where A1-C1-C6-alkylene; R1-C1-C6-alkyl, trifluoromethyl, C3-C6-cycloalkyl, C1-C4-alkoxy-C1-C4-alkyl or a group: R3-A2 at R3 pyridyl, phenyl, non- or mono- or disubstituted with hydrogen, trifluoromethyl, nitro or cyano-group, and A2 0 C1-C6-alkylene, hydroxy-C1-C6-alkylene, C2-C6-alkenylene or direct bond with R3; R2 - hydroxy-group, or physiologically acceptable alcohol moiety; X hydrogen, hydroxide or C1-C4-alkoxy-group; Y vinylene, n=1 or 2, or their pharmaceutically salt. For substances of the formula (I) the value pA2 showing antagonism TXA2 capability is 5.4-7.95 rel. units. Synthetase inhibition is carried out by using microsomatic method, and results are 0.05-0.31 μm. Synthesized compounds were used in medicine. The formula (I) is given in the description of invention. EFFECT: increased effectiveness of synthesized compounds.

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RU 2 040 525 C1

Authors

Ehndrju Dordzh Brjuster[Gb]

Dzhorzh Robert Braun[Gb]

Alan Villington Foll[Gb]

Redzhinal'D Dzhessup[Gb]

Majkl Dzhejms Smiters[Gb]

Dates

1995-07-25Published

1989-02-15Filed