FIELD: organic chemistry, antibiotics. SUBSTANCE: product: macrolide compounds of the general formula (I) 
where: R1 - [N(CH3)2R]+X⊖ or N(CH3)2 where R - C1-C6-alkyl or C2-C6-alkynyl; R2 and R3 - each H or form together the simple bond; R4 and R5 are independently each of other H or together with carbonyl-group form five-membered cyclic carbonate; R6 - H; X⊖ - halide at condition that if R1 - N(CH3)2 and R2 and R3 form together the simple bond then R4 and R5 can not be hydrogen. Pharmaceutical composition based on compound (I) 
taken at amount 0.1-9 wt.-% per the dosed unit can be used in medicine for treatment of gastroenteric tract disorders. EFFECT: improved method of synthesis. 5 cl, 2 tbl
