FIELD: veterinary microbiology, biotechnology. SUBSTANCE: serum has complex of antibodies against somatic antigens 09, 078, 0141, protein somatic ones K88, K99, 987P, F41 and polysaccharide capsule ones K30, K80, K87 providing neutralization of escherichia pathogenic action in animals of different species. Method of serum preparing involves preparing polyvalent antigen, hyperimmunization of bullock-producers, blood taking away, separation and preserving serum. Serum is used for treatment and prophylaxis of escherichiosis in newborn calves, piglets, lambs and foals. EFFECT: enhanced effectiveness of serum, improved method of preparing. 6 tbl
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