FIELD: veterinary microbiology, biotechnology. SUBSTANCE: vaccine has antigens of escherichia: somatic 078, 0141, protein adhesive antigens K88, K99, 987P, F41, capsule polysaccharide K80, K87, TL, TC anatoxins providing the synthesis of specific antibodies in blood of immunized animals that inhibit the main processes of coli-infection development colony-forming of pathogen in intestine of animals and neutralization of endo- and enterotoxins. For prophylaxis of escherichiosis in newborns vaccine is administrated to pregnant animals twice at interval 12-14 days 1.5-2 months before confinement, and also to piglet and lambs before weanling. EFFECT: enhanced effectiveness of vaccine. 4 tbl
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