POLYSPECIFIC ROTA-, CORONAVIRAL GASTROENTERITIS AND PIG COLIBACILLOSIS DIARRHEA HYPERIMMUNE SERUM Russian patent published in 2012 - IPC A61K39/395 C07K14/08 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to veterinary microbiology and biotechnology. A polyspecific serum contains specific rotavirus min. 1:12800 (ELISA), coronavirus min. 1:12800 (ELISA), E. coli producing adhesive antigens K88, K99, 987P min. 1:3200 (AG), thermostable and thermally labile anatoxin E.coli 1:4 (DPR) antibody titres. The serum is prepared by hyperimmunisation of producer pigs by a polyvalent viral antigen containing a mixture of culture viral suspensions of rotavirus and porcine transmissible gastroenteritis of the concentration 10-12 mg/cm³ of a specific protein intramuscularly, and with a polyvalent escherichia antigen containing inactivated suspensions of E. coli cells with adhesive antigens K88, K99 and 987P with each strain in the concentration 10-15 billion m.c. per 1 cm³ of physiologic saline; anatoxin titres in the culture medium (DPR) 1:4 - 1:8 intramuscularly that is followed by blood sampling, serum separation and preservation. The polyspecific serum is applicable for the purpose of prevention and treatment in threatened and stable disadvantaged farms with rota-, coronavirus and porcine colibacillosis diarrhoeah. The invention may be used in veterinary science.

EFFECT: animals immunised with the polyspecific serum show immunity developing on the following day and preserved for 12-14 days.

5 tbl, 7 ex