ASSOCIATED VACCINE AGAINST ANAEROBIC ENTEROTOXEMIA AND COLIBACILLOSIS DIARRHEA IN CALVES Russian patent published in 2011 - IPC A61K39/116 A61K39/108 A61K39/08 A61P31/04 

FIELD: medicine.

SUBSTANCE: invention refers to veterinary microbiology. The vaccine contains the following components related to 1 l of the vaccine: suspension of No. 28 Cl.perfringens type A strain cells in a culture medium in the concentration 3.5·10¹²-4.0·10¹², cm³ - 140.0-160.0; suspension of No.392 Cl.perfringens type C strain cells in a culture medium in the concentration 3.5·10¹²-4.0-10¹², cm³ - 140.0-160.0; suspension of No.213 Cl.perfringens type D strain cells in a culture medium in the concentration 3.5·10¹²-4.0·10¹², cm³ - 140.0-160.0; suspension of E.coli KB-1 strain cells containing adhesive antigen K99 in physiologic saline in the concentration 100·10¹²-120·10¹², cm³ - 25.0-30.0, suspension of E.coli "ПЗ-3" strain cells containing adhesive antigen A20 in physiologic saline in the concentration 100·10¹²-120·10¹², cm³ - 25.0-30.0; 6% aluminium hydroxide, cm³ - 200.0-250.0; formalin, cm³ - 4.0-5.0; thermolabile and thermostable anatoxin of E.coli K99 and E.coli "ПЗ-3" strains in the ratio 1:1 in a culture medium with titre in "РДП" 1:8-1:16, l - to 1 l.

EFFECT: vaccine causes expressed immunity formation in young and adult cattle for 12 months after double vaccination; the calves produced by vaccinated cows show 1,5-month colostral immunity formation after colostrum intake.

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