INACTIVATED COMBINED VACCINE AGAINST VIRAL DIARRHEA, ROTA-, CORONA-VIRUS DISEASES AND ESCHERICHIOSIS OF CATTLE Russian patent published in 2010 - IPC A61K39/295 A61P31/00 

FIELD: medicine, veterinary.

SUBSTANCE: invention relates to field of veterinary microbiology. Vaccine contains active substance and target additives. As active substance vaccine contains mixture of inactivated suspension of strain of cattle diarrhea virus SCV No 2336, family Flaviviridae, genus Pestivirus, inactivated suspension of strain of rotavirus SCV No 2337, family Reoviridae, genus Rotavirus; inactivated suspension of strain of coronavirus SCV No 2338, family Coronaviridae, genus Coronavirus, with activity of each of virus strains not lower than 10^6.5 TCD₅₀ in 1 cm³ of vaccine, and inactivated suspension of cells of bacteria Escherichia coli serovariants O9:K30, O78:K80, O115, O141 :K99 and O101:F41, taken in mixture in equal proportion with concentration not less than 20 billion microbial cells in cm³ of vaccine.

EFFECT: vaccine is superior to known vaccines in spectrum of specific protection and efficiency of activity for sensitive group of animals, duration of expressed immunity, safety for animals in calf and newborn calves, in stability of preservation of biological properties, including antigenic and immunogenic activity for 18 months (observation term).

3 cl, 8 tbl, 5 ex