BIPHENYL DERIVATIVES AND METHOD OF PREPARING THEREOF Russian patent published in 1998 - IPC

FIELD: medicine. SUBSTANCE: present invention describes compounds of formula (I): wherein A is group IIa, IIb or IIc: , , wherein R¹ is alkyl, alkenyl, cycloalkyl or group of formula: R⁴-Y-R⁵ wherein R⁴ is hydrogen, alkyl or cycloalkyl; R⁵ is single bond or alkylene and Y is oxygen, sulfur or imino group; R² is hydrogen, halogen optionally substituted alkyl, optionally substituted alkenyl, optionally substituted cycloalkyl, formyl, alkylcarbonyl, hydroxy, amino, alkylamino, dialkylamino, alkoxy, alkylthio, cyano or nitro group; R³ is hydrogen, alkyl, carboxy or substituted carboxy group, carbamoyl or tetrazol-5-yl; X is group of formula CH=, -N= or C(COOR)⁶ wherein R⁶ is hydrogen or protecting radical for carboxy group; Z is single bond, alkylene or vinylene and B is carboxy or substituted carboxy group or tetrazol-5-yl, and pharmaceutically acceptable salts and esters thereof are capable of inhibiting angiotensin and are useful for treatment and prophylaxis of hypertension and cardiac diseases. EFFECT: improved properties of the title compounds. 49 cl, 6 dwg , 3 tbl