FIELD: medicine, as antagonist of receptor of serotonine-2. SUBSTANCE: diaryl alkanes have formula I where R1 is aryl, R2 is H, R3 is -BNR4R5, group where R4 and R5 is H, alkyl, or R4 and R5 together with nitrogen atom which with they are bound represent heterocyclic group comprising 3-6 ring atom and B is alkylene C2-C6 group or -D-R7 group where D is single carbon-carbon bond or alkylene group, A is C2-C8 alkylene group. Compound having formula II
is used as reagent 1. Compound having formula Z-B-NR4R5 where Z is OH group or group enables splitting, B, R4 and R5 are as it mentioned above is used as reagent 2. Compound or its pharmaceutically acceptable salts may be used in medicine. EFFECT: improved quality.
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Authors
Dates
1998-02-27—Published
1993-11-30—Filed