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2 045 575

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IPC

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Application

5024478/13, 1992-01-29

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Actual filing date

1992-01-29

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Published

1995-10-10

(72)

Inventor

Mashko S.V.Lebedeva M.I.Vinetskij Ju.P.Kotenko S.V.Ketlinskij S.A.Simbirtsev A.S.Kozlov A.P.Izotova L.S.Kozlov Ju.I.Debabov V.G.

(73)

Holder

Gosudarstvennyj Nauchno-Issledovatel'Skij Institut Genetiki I Selektsii Promyshlennykh Mikroorganizmov

RECOMBINANT PLASMIDE DNA PPR-TGATG-HIL-Iβ-TSR WHICH PROVIDES SYNTHESIS OF RECOMBINANT INTERLEIKIN-1 AND STRAIN BSCHERICHIA COLI BEING PRODUCER OF RECOMBINANT HUMAN INTERLEIKIN-1 b Russian patent published in 1995 - IPC

Abstract RU 2045575 C1

FIELD: microbiological and medicinal industries, molecular biology, biotechnology. SUBSTANCE: with the help of prepared plasmide pPR-TGATG-hIL-Iβ-tsr strain E. coli is obtained. Said strain produces human interleikin-1 b, its quantity being 5-10 mg per 1 g of humid cells or 10-12 of total cellular protein. Specific activity thus prepared interleikin is 2×10⁸ IU per 1 mg of purified preparation. EFFECT: improves quality of desired product. 3 cl, 3 dwg

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RU 2 045 575 C1

Authors

Mashko S.V.

Lebedeva M.I.

Vinetskij Ju.P.

Kotenko S.V.

Ketlinskij S.A.

Simbirtsev A.S.

Kozlov A.P.

Izotova L.S.

Kozlov Ju.I.

Debabov V.G.

Dates

1995-10-10—Published

1992-01-29—Filed