QUINONE DERIVATIVE AND ITS PHARMACOLOGICALLY ACCEPTABLE SALTS Russian patent published in 1995 - IPC

Abstract RU 2049776 C1

FIELD: organic chemistry. SUBSTANCE: product: derivatives of quinone of the formula (I) where R′ heteroalkyl group in which heteroalkyl is five- or six-membered cycle containing nitrogen as a heteroatom. Alkyl component has 1-10 carbon atoms; B carboxy or carboxy-protected group; R3,R4,R5 are similar or distinct groups and each means hydrogen atom, hydroxyl group, C1-C8-alkyl, C1-C8-alkoxy, C1-C8-alkoxy, C1-C10-alkyl, C1-C8-alkoxym C1-C8-alkoxy, C3-C7-cycloalkyl-C1-C8-alkoxy, thio-C1-C8-alkyl, thio-C1-C8-alkyl, for exception, when R3 and R4 is simultaneously lower C1-C8-alkoxy-group or a group of the formula (II) in which R3,R4,R5 have meanings indicated above; X and Y are similar or different and each means hydroxyl or C1-C8-alkoxy. Compound (I) or its pharmacologically acceptable salts show inhibitory activity with respect to synthesis of leukotrienes and thromboxanes and can be used in medicine as therapeutic agents. EFFECT: improved method of synthesis. 11 cl, 20 tbl

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RU 2 049 776 C1

Authors

Jasusi Okamoto[Jp]

Katsuja Tagami[Jp]

Sigeki Khibi[Jp]

Khirotosi Numata[Jp]

Tetsuja Kavakhara[Jp]

Naoki Kobajasi[Jp]

Masanobu Sinoda[Jp]

Koukiti Kharada[Jp]

Kaname Mijamoto[Jp]

Koiti Abe[Jp]

Dates

1995-12-10Published

1992-03-10Filed