FIELD: medicine. SUBSTANCE: product: N-acetyl-a-glutamic acid, mp 195-196 C, yield 82-85%, [a]=16.7 C. Reagent 1: [α]D glutamic acid. Reagent 2: acetic anhydride. Reaction conditions: in aqueous acetone solution containing 0.6-0.2 wt parts per 1 wt part of α-glutamic acid. Initial process temperature is 30-35 C and reaction temperature is not higher than 100 C. EFFECT: more efficient preparation process. 2 dwg
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Authors
Dates
1996-10-27—Published
1992-06-24—Filed