FIELD: organic chemistry. SUBSTANCE: product: new derivatives of methylenehydroxyindole of the formula , where R - group where R4 - hydrogen, hydroxy, (C1-C6)-alkoxy, (C2-C6)-alkanoylhydroxy, carboxy, nitro-group or group NHR7 where R7 means hydrogen or (C1-C6)-alkyl; R5 - hydrogen, (C1-C6)-alkyl or halogen; R6 - hydrogen or (C1-C6)-alkyl; n = 0, 1 or 2; R1 - hydrogen, (C1-C6)-alkyl or (C2-C6)-alkanoyl; R2 - hydrogen, (C1-C6)-alkyl, halogen, cyano-, carboxyl, nitro-group or group -NHR7 where R7 - as indicated above; R3 - hydrogen, (C1-C6)-alkyl or (C2-C6)-alkanoyl, and their pharmaceutically acceptable salts where: when R2 is simultaneously hydrogen, (C1-C6)-alkyl, halogen or cyano-group and R3 means hydrogen, R1 and have values indicated above and then at least one of substituent R4,R5 and R6 is not hydrogen. Synthesized compounds were used as tyrosine kinase inhibitors. EFFECT: improved method of synthesis.
Authors
Dates
1997-02-10—Published
1992-07-10—Filed