PEPTIDE DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, METHOD OF SYNTHESIS OF PEPTIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITION Russian patent published in 1997 - IPC

FIELD: chemistry of peptides. SUBSTANCE: product: peptide derivatives of the general formula (I): R₁-A-CH₂-(R₂)-CON(R₇)-CH₂(R₃)-CON(R₆)-CO(R₄)R₅ where: R₁ - hydrogen or acyl; R₂ - lower alkyl, aryl-(lower)-alkyl; (C₃-C₇)-cycloalkyl-(lower)-alkyl; heterocyclic-(lower)-alkyl where heterocyclic group is the unsaturated 5,6-membered heteromonocyclic group containing 1-2 nitrogen atoms optionally substituted with imino-protective group; R₃ - heterocyclic-(lower)-alkyl being heterocyclic group can be unsaturated fused 9-membered one containing one nitrogen atom and optionally substituted with a suitable substituent taken from (lower)-alkyl and imino-protective group, aryl-(lower)-alkyl; R₄ - H, aryl-(lower)-alkyl, (lower)-alkyl, amino-(lower)-alkyl (free or protective one) and free or protective heterocyclic-(lower)-alkyl; heterocyclic group can be the unsaturated 5-6-membered one containing 1 or 2 nitrogen atoms or one sulfur atom and one nitrogen atom and optionally substituted imino-protective group; R₅ - carboxy, protected carboxy, carboxy-(lower)-alkyl (free or protected one); R₆ - H, heterocyclic-(lower)-alkyl where heterocyclic group is the saturated 6-membered heterocycle with one nitrogen atom; R₇ - H or (lower)-alkyl; A - -O-, NH, (lower)-alkylimino, lower alkylene, or their pharmaceutically acceptable salts. Method of synthesis of compounds of the formula (I) involves condensation of two fragments R₁ACH₂(R₂)-COOH and R₇NHCH(R₃)CON(R₆)CH(R₄)R₈, and pharmaceutical composition containing pharmaceutically acceptable carrier and peptide derivative of the formula (I) as an active component taken at effective dose. The synthesized compounds were used in medicine for hypertension treatment and prophylaxis. EFFECT: improved method of synthesis. 8 cl