PYRROLIDINE DERIVATIVES AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF Russian patent published in 1997 - IPC

Abstract RU 2095346 C1

FIELD: pharmaceutical industry. SUBSTANCE: present invention describes pyrrolidine derivatives of formula 1: wherein R1 is heteryl(lower)alkyl, (C1-C12) alkyl and optionally substituted phenyl (lower) alkyl; R2 is H, phenyl (lower)alkoxycarbonyl or optionally substituted phenylsulphonyl; R3 is carboxy (lower) alkyl, etherified carboxylower alkyl, carboxyphenyl or etherified carboxyphenyl and pharmaceutically acceptable salts thereof. Said salts are prepared by reacting compound of formula II: with compound of formula XIV: or salt thereof. Present invention describes pharmaceutical composition which has antagonistic activity against thromboxane A2(TXA2) and inhibits TXA2 synthase based on compound I. EFFECT: improved properties of the pharmaceutical composition. 9 cl

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RU 2 095 346 C1

Authors

Khirojuki Setoi[Jp]

Akikhiko Savada[Jp]

Khirokazu Tanaka[Jp]

Masaki Khasimoto[Jp]

Dates

1997-11-10Published

1991-10-16Filed