FIELD: organic chemistry and technology. SUBSTANCE: invention describes two methods of synthesis of 4-amino-2-(4-methylpiperazine-1-yl)-5-(2,3,5-trichlorophenyl)- -pyrimidine or its acid additive salt. a) Reagent 1: 1-(2,3,5-trichlorophenyl)-3-alkoxyacrylonitrile. Reagent 2: N-methylpiperazineformamide or its salt. b) Reagent 1: 2-(2,3,5-trichlorophenyl)-3-acetalpropionitrile. Reagent 2: N-methylpiperazineformamide. Synthesized compound is isolated as the base of its acid additive salt. Synthesized compound is used in medicine. EFFECT: improved method of synthesis. 2 cl, 1 tbl
| Title |
Year |
Author |
Number |
| 4-AMINO-2-(4-METHYLPIPERAZINE-1-YL)-5-(2,3,5-TRICHLOROPHENYL)- -PYRIMIDINE AND ITS SALTS OF ACID ADDITION, METHODS OF THEIR SYNTHESIS (VARIANTS) AND PHARMACEUTICAL COMPOSITION |
1989 |
- Miller Ehlistehjr Ehjnsli
- Nobbz Mal'Kol'M Stjuart
- Gajd Richard Martin
- Lich Majkl Dzhon
|
RU2171256C2 |
| METHOD OF PREPARING SUBSTITUTED 5-ARYL-PYRIMIDINES |
1991 |
- Majkl Dzhon Lich[Gb]
- Mal'Kol'M Stjuart Nobbz[Gb]
- Ramachandran Ijer[Gb]
- Klajv Leonard Jits[Gb]
- Filip Alan Skoun[Gb]
|
RU2091374C1 |
| PYRIMIDINE DERIVATIVES, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION |
1989 |
- Ehlistehjr Ehjnsli Miller
- Mal'Kol'M Stjuart Nobbz
- Richard Martin Gajd
- Majkl Dzhon Lich
|
RU2121998C1 |
| ENANTIOMERIC COMPOUNDS AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF |
1992 |
|
RU2091386C1 |
| METHOD OF SYNTHESIS OF ENANTIOMERIC COMPOUNDS OR THEIR DERIVATIVES |
1990 |
|
RU2068849C1 |
| METHOD FOR TREATING AND/OR PROPHYLAXIS OF PROTOZOAN PARASITARY INFECTION, USE OF ATOVACUON AND PROGUANYL FOR PRODUCING MEDICINAL PREPARATION FOR TREATING PROTOZOAN INFECTIONS, COMBINATION OF ATOVACUON WITH PROGUANYL FOR TREATING PROTOZOAN INFECTIONS, USE OF SAID COMBINATION AND PHARMACEUTICAL PREPARATION |
1993 |
- Uinston Ehdvard Gatteridzh[Gb]
- Dehvid Brajan Ehshton Khatchinson[Gb]
- Viktorija S'Juzn Lehtter[Gb]
- Mehri Padni[Gb]
|
RU2108092C1 |
| N,N-DIMETHYL-2-(5-(2-OXO-1,3-OXAZOLIDINE-4-YL-METHYL)-1H-INDO- -LE-3-YL)-ETHYLAMINE, ITS PHYSIOLOGICALLY ACCEPTABLE SALT OR SOLVATE, METHOD OF ITS SYNTHESIS, DRUG USED AS AN AGONIST OF "5-HT-LIKE" RECEPTOR IN MAMMALS, METHOD OF DRUG AGENT PREPARING |
1991 |
- Alan Dunkan Robertson[Gb]
- Alan Piter Khill[Gb]
- Robert Cherl'Z Glen[Gb]
- Grehm Richard Martin[Gb]
|
RU2110517C1 |
| METHOD OF PRODUCING TRIAZINE OR ACID-ADDITIVE SALTS THEREOF |
0 |
- Dzheffri Allan
- Alistejr Ajnsli Miller
- David Alan Sojer
|
SU1371500A3 |
| METHOD OF PRODUCING BICYCLIC COMPOUNDS OR ADDITIVE SALTS OF HYDROCHLORIC ACID THEREOF |
0 |
|
SU1384200A3 |
| APPLICATION OF 5-ETHYNYLURACIL AS AN ACTIVATOR OF URACIL-REDUCTASE, PHARMACEUTICAL COMPOSITION, METHOD FOR ITS OBTAINING, PHARMACEUTICAL COMPOSITION FOR INCREASING THE ACTION OR DECREASING THE TOXICITY OF 5-FLUOURACIL |
1991 |
- Spektor Tomas
- Porter Dehvid Dzhon Timoti
- Rakhim Saad Dzhordzh
|
RU2194511C2 |
