PYRIMIDINE DERIVATIVES, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION Russian patent published in 1998 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to the substituted phenylpyrimidine compounds of the formula (I) where R₁ means NH₂, N-alkylamino-, N,N-dialkylamino-groups; R₂ means NH₂; R₃ means trifluoromethyl- or CH₂X where X means C₁-C₆-alkyl, phenoxy-, benzylhydroxy-, hydroxy- or halogen atom; R₄ and R₅ each means halogen; R₆-R₈ each means hydrogen, and its pharmaceutically acceptable acid-additive salts that are power inhibitors of exciting amino acid, glutamate. Method of synthesis of compounds of the formula (I) involves interaction of compounds of the formula (III): R₁C(=NH)NH₂ with compounds of the formula (II) and (V) . The proposed composition contains an effective amount of compound of the formula (I) or its pharmaceutically acceptable salt as an inhibitor of glutamate release. The synthesized compounds can be used for treatment or prevention of some damages in central nervous system involving cerebral ischemic disorder and epilepsy. EFFECT: improved method of synthesis, enhanced effectiveness of composition. 9 cl, 2 tbl, 4 ex