FIELD: organic chemistry and technology. SUBSTANCE: product: N-acylamino-1-hydroxyalkylidene-1,1-bis-phosphonic acids of the formula RNH-A-G(OH)-[PO3H2] 2 where: A - (CH2)3 - or -(CH2)5-; R - ibuprofen residue. Reagent 1: RCOCl where R - as indicated above. Reagent 2: H2N-A-C(OH)[PO3H2]2 where A - as indicated above. Reaction conditions: in an aqueous medium, in the presence of alkali. Synthesized compounds were used in medicine as antiinflammatory agents. EFFECT: improved method of synthesis. 3 cl, 2 tbl
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Year |
Author |
Number |
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