DERIVATIVES OF DIPYRIDO-DIAZEPINE AND THEIR HYDRATES SHOWING BIOLOGICAL ACTIVITY Russian patent published in 1995 - IPC

FIELD: organic chemistry. SUBSTANCE: product: derivatives of dipyrido-diazepine and their hydrates of the formula (I) where Z oxygen, sulfur, group NCN or -NOR⁹, at R⁹ - alkyl; R¹ hydrogen, hydroxyl, alkyl, alkenyl, alkenylhydroxycarbonyl, alkoxyl, alkanoyl, dialkylaminoethyl, alkoxyalkyl, alkylthioalkyl, benzyl; R² hydrogen, alkyl, fluoroalkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, alkoxyalkyl, alkylthioalkyl, alkanoyl, cyano, phenyl, benzyl, alkoxybenzyl, methylsulfonyl; R³ hydrogen, hydroxyl, halide, nitro, alkyl, alkoxy, amino, mono- or dialkylamino, alkenylamino, pyrrolidine-1-yl, pyrroline-1-yl, tetrahydropyridine-1-yl, morpholine-1-yl, piperidine-1-yl, methoxybenzylmethylamino, methoxybenzylamino; R⁴ hydrogen, halide, alkyl, nitro, amino; R⁵ hydrogen, hydroxyl, halide, alkyl, alkoxy, trihalidemethyl, hydroxyalkyl, cyano; R⁶ hydrogen, hydroxyl, alkyl; R⁷ hydrogen, halide, azido, nitro, amino, alkyl; R⁸ - hydrogen, alkyl, and in all cases mentioned above alkyl is lower one. Synthesized compounds were used in pharmacology. EFFECT: improved method of synthesis. 2 cl, 2 tbl