FIELD: organic chemistry. SUBSTANCE: product - derivatives of dipyrido-diazepine of the formula (I), where Z - O or S; R1 - H, Alk, alkoxy, alkanoyl, alkylthioalkyl or benzyl; R2 - H, Alk, alkoxy, fluoroalkyl, alkenyl, alkinyl, alkylthioalkyl, alkanoyl, benzyl, alkoxybenzyl; R3 - R8 are similar or different and mean H, alkyl, alkoxyl, amino, hydroxy, alkylamino, haloid, nitro-group. These compounds show inhibiting effect on the activity of reverse transcriptase of HIV-1 virus. Formula (I) (image). EFFECT: improved method of synthesis. 2 cl, 2 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| DERIVATIVES OF DIPYRIDO-DIAZEPINE AND THEIR HYDRATES SHOWING BIOLOGICAL ACTIVITY | 1992 |
|
RU2040527C1 |
| 2-HETEROARYL-5,11-DIHYDRO-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]-DIAZEPINE-6-ONES, THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, PHARMACEUTICAL COMPOSITION SHOWING INHIBITORY ACTIVITY WITH RESPECT TO HIV-1 REVERSE TRANSCRIPTASE | 1995 |
|
RU2142464C1 |
| HETEROCYCLIC NITROGEN CONTAINING COMPOUNDS AS RACEMATES OR INDIVIDUAL ENANTIOMERS WHICH ARE LEUKOTRIENE BIOSYNTHESIS INHIBITORS | 1992 |
|
RU2080321C1 |
| BENZIMIDAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITION SHOWING ANTAGONISTIC ACTIVITY WITH RELATION TO ANGIOTENSIN BASED ON THEREOF | 1992 |
|
RU2053229C1 |
| DIAZEPINONE DERIVATIVES, METHODS OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION | 1992 |
|
RU2081870C1 |
| CYCLIC NITROGEN-CONTAINING DERIVATIVES, MIXTURE OF THEIR ISOMERS, INDIVIDUAL ISOMERS OR THEIR SALTS | 1994 |
|
RU2126002C1 |
| FUSED 5-MEMBER HETEROCYCLES OR THEIR SALTS SHOWING ACTIVITY BY AGGREGATION INHIBITION | 1992 |
|
RU2041211C1 |
| DERIVATIVES OF PYRIDYL, MIXTURE OF THEIR ISOMERS, OR INDIVIDUAL ISOMERS, OR THEIR PHYSIOLOGICALLY TOLERATED ADDITIVE SALTS SHOWING BIOLOGICAL ACTIVITY | 1991 |
|
RU2028292C1 |
| DERIVATIVES OF PYRIDINE, THEIR ENANTIOMERS, CIS- OR TRANS-ISOMERS AND THEIR SALTS AND PHARMACEUTICAL COMPOSITION | 1992 |
|
RU2119915C1 |
| PROCESS FOR PREPARING DIAZEPINONE DERIVATIVES | 0 |
|
SU1103795A3 |
