PEPTIDES, METHOD OF THEIR SYNTHESIS, AGENT SHOWING BRADYKININ-ANTAGONISTIC ACTIVITY Russian patent published in 1998 - IPC

FIELD: biologically active peptides. SUBSTANCE: product: peptides of the formula (I): Z-P-A-B-C-E-F-K-(D)Q-G-M-F′-Y where Z means 9-fluorenylmethyloxycarbonyl (Fmoc), dibenzyl acetate, cyclohexylcarbonyl, N,N-dibenzylglycyl, 2-(4-isobutylphenyl)- -propionyl, 2-R-(tert.-butylsulfonylmethyl)-3-(1-naphthyl)- -propionyl-indole-3-yl-acetyl, 6-(4-benzoylbenzoylamino)-hexa- -noyl-1,8-naphthalimidoacetyl, 7-theophylline-acetyl or N-benzoyl; P means direct bond, Aoc, ε-aminohexanoyl; D - Aoc, Aeq (Fmoc), 4-aminocyclohexylcarbonyl or Oic; A means (D)- or (L)-Arg, (D)- or (L)-Lys or bond; B means Arg; C means Pro-Hyp-Gly; E means Thia; F means Ser; K means direct bond; Q means Tic; M means direct bond; G means cis-endo, cis-exo, trans-octahydroindole-2-carboxylic acid; F′ means Arg and Y means OH. Peptides (I) are synthesized by solid-phase method. Peptides are incorporated as an active component at effective amount to agent showing bradykinin-antagonistic activity and can be used in medicine. EFFECT: improved method of synthesis. 16 cl, 3 tbl