PEPTIDES AND THEIR PHYSIOLOGICALLY ACCEPTABLE SALTS Russian patent published in 1997 - IPC

FIELD: organic chemistry, peptides. SUBSTANCE: product: peptide derivatives of the general formula (I): A-B-C-E-F-K-(D)-G-M-F¹-Y where: A - H, acetyl, D-Tyr, Lys, Arg, D-Arg and the latter is substituted with 4-hydroxyphenylpropinyl or acetyl; B - L- or D-Arg or Lys that can be substituted at by-side chain with NO₂, Tos, nicotinoyl, CONH-C₆H₅, BOC, 4-MeO-2,3,6-trimethylphenylsulfonyl or bond; C - Hyp-Pro-Gly; Pro-Hyp-Gly; Pro-Pro-Gly, dehydro-Pro-Hyp-Gly and D-Pro-Hyp-Gly; E - Phe, Thia, Trp, D-Thia; F - Ser, D-Ser, Gln, Trp, D-Asn, Cys or the bond; K - Gly, β-Ala or the bond; G - Pro, Aoc, Tic, Oic, D-Oic, (D,L)-Oic, (L)-(3aS, 7aR)-Oic, (L)-(3aR, 7aS)-Oic, or the bond; M - Phe, Thia or the bond; F¹ - Arg that can be substituted at by-side chain with 4-MCO-2,3,6-trimethylphenylsulfonyl or D-Arg, or D-Ser (Rha) or the bond; Y - OH or NH₂, or their pharmaceutically acceptaable salts. Synthesized peptides show bradikinin-antagonistic effect and can be used in medicine. EFFECT: improved method of synthesis. 6 vl, 1 tbl