FIELD: biotechnology, medicine, oncology. SUBSTANCE: invention relates to method of preparing insoluble form of recombinant human alpha-interferon. Method involves preparing a mixture of mono-, di- and oligomers of human recombinant alpha-2-interferon at molecular-weight distribution from 17 to 5000 kDa by reduction of disulfide bonds in recombinant protein and oxidation of the formed thiols. Insoluble form can be obtained from water-soluble recombinant human alpha-2-interferon or directly from body inclusion forming in cells of the strain-superproducer. EFFECT: simplified method, increased stability of the end product. 3 cl, 5 tbl
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