METHOD OF HYDROXYTETRACYCLINE PRODUCING Russian patent published in 1997 - IPC

FIELD: medicinal industry, antibiotics. SUBSTANCE: method involves culturing the strain Streptomyces rimosus on nutrient medium containing sources of nitrogen, carbon, mineral salts at aeration, stirring, control for ammonium nitrogen content and pH value. In the process of culturing additional addition of carbon-containing substrate is carried out at amount to maintain viscosity of cultural fluid at the level (60-100) x 10^-3 Pa x s, and the first addition is carried out at cultural fluid viscosity 60 x 10^-3 Pa x s. EFFECT: improved method of hydroxytetracycline production.