METHOD OF PREPARING SERA CONTAINING ANTIBODIES RAISED TO MARBURG VIRUS Russian patent published in 1997 - IPC

Abstract RU 2085214 C1

FIELD: virology, biotechnology. SUBSTANCE: method involves two- or three-stage immunization of monkey Cercopithecus aethiops with the purified inactivated viral antigen with Freund's adjuvant to obtain the necessary antibody level in animal blood to Marburg virus at titer by "ИФА" 1:640 (not less) and the following infection that is carried out once or twice. The first dose at infection is 1-10 LD₅₀ and at the second one - 10-100 LD₅₀. Method can be used for preparing diagnostic agents and sera for Marburg virus control. EFFECT: improved method of preparing. 1 tbl

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RU 2 085 214 C1

Authors

Frolov V.G.

Shestopalov A.M.

Nikolenko N.I.

Vjazunov S.A.

Agafonova O.A.

Dates

1997-07-27—Published

1995-04-28—Filed