CHIMERIC PEPTIDE IMMUNOGENIC LIBRARY MIMICKING GENETIC DIVERSITY OF HYPERVARIABLE REGION OF PROTEIN V3 OF HUMAN IMMUNODEFICIENCY VIRUS ENVELOPE GP120 Russian patent published in 2004 - IPC

FIELD: medicine, biotechnology, virology.

SUBSTANCE: invention relates to diagnosis and vaccine-prophylaxis of HIV-1. Invention proposes library of chimeric peptides mimicking the genetic diversity of the main hypervariable region V3 in HIV-1 gp120. Library is immunogenic and causes producing antibodies interacting with the broad spectrum of gp120 variants of different HIV-1 genotypes. Also, the library elicits ability to bind early antibodies raised against to HIV-1. In immunization of laboratory animals with chimeric peptides library the specific antibodies are formed that interact with the broad variant of gp120 of different HIV-1 genotypes. The proposed library of chimeric peptides can be used for preparing antigens for producing diagnostic test-systems and manufacturing vaccine against HIV-1.

EFFECT: valuable biological and medicinal properties of library.

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