VACCINE AGAINST VIRAL INFECTIONS Russian patent published in 2003 - IPC

Abstract RU 2217162 C2

FIELD: biotechnology, medicine, biochemistry, immunology. SUBSTANCE: invention relates to vaccine that represents particles 25-30 nm by diameter containing polynucleotide complex (recombinant plasmid DNA comprising genes of infectious agent or double-stranded RNA-stimulator of nonspecific resistance of organism) in center and fused protein on surface comprising epitopes (polypeptides) of infectious agent and enzyme (for example, glutathione S- transferase or β- galactosidae). Linkage between polynucleotide complex and fused proteins is carried out conjugate : spermidine (for linkage of conjugate with polynucleotide complex) polyglucine- substrate for enzyme (for example, glutathione or galactopyranoside) for affinity sorption of fused proteins for construction. Vaccine provides the broader titer of antibodies and more prolonged immune response in immunization. EFFECT: enhanced effectiveness and valuable medicinal properties of vaccine. 6 dwg, 4 ex

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RU 2 217 162 C2

Authors

Lebedev L.R.

Karpenko L.I.

Il'Ichev A.A.

Dates

2003-11-27—Published

2000-04-10—Filed