RECOMBINANT ATTENUATED STRAIN OF BACTERIUM SALMONELLA ENTERIDITIS E-23/PGEX-2T-TBI AS CANDIDATE FOR CONSTRUCTION OF LIVE VACCINE AGAINST HUMAN IMMUNODEFICIENCY VIRUS Russian patent published in 2004 - IPC

Abstract RU 2237089 C2

FIELD: biotechnology, medicine, genetic engineering, vaccines.

SUBSTANCE: invention proposes the recombinant attenuated strain of bacterium Salmonella entiriditis E-23/pGEX-2T-TBI producing artificial protein TBI consisting of T- and B-cellular epitopes of HIV-1. The strain is obtained by genetic transformation of the strain Salmonella entiriditis E-23 (cya, CRP) with plasmid pGEX-2T-TBI. The recombinant microorganism strain administrated in animals induces the expressed specific humoral and cellular immune response to HIV-1. The recombinant strain can be used for construction of live vaccine against HIV-1.

EFFECT: valuable biological and medicinal properties of strain.

2 tbl, 5 dwg, 4 ex

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RU 2 237 089 C2

Authors

Karpenko L.I.

Nekrasova N.A.

Ignat'Ev G.M.

Il'Ichev A.A.

Bojchenko M.N.

Vorob'Ev A.A.

Dates

2004-09-27—Published

2002-10-31—Filed