CYCLOPEPTOLIDE, FUNGUS STRAIN, METHOD OF CYCLOPEPTOLIDE PRODUCING, THERAPEUTIC COMPOSITION Russian patent published in 2000 - IPC

FIELD: organic chemistry, peptides. SUBSTANCE: invention relates to a novel class of cycloheptapeptolides of the formula (I) where A, B, R₁, Leu, C, X and Y are given in the invention claim. This compound is obtained by culturing the fungus strain Bartalina sp. NRRL 21123 on nutrient medium followed by isolation of indicated compound from medium. Invention describes also producing the therapeutic agent showing the ability to inhibit expression of adhesion molecules involving the compound of the formula (I) as an active component taken in effective amount and special additions also. Invention relates to also therapeutic use of compounds as inhibitors of expression of adhesion molecules used for treatment of many morbid states. EFFECT: improved method of producing, enhanced effectiveness of agent. 6 cl, 6 tbl, 7 dwg