FIELD: organic chemistry, biochemistry, nucleic acids. SUBSTANCE: product: oligonucleotides of the general formula (I): 
where: R1 - H or residue of the formula (II): 
where: R2 - H or residue of the formula (III): 
where: B - adenine, thymine, cytosine or guanine; W and W′ - oxygen atom; Z and Z′ - independently O-C1 - C3-alkoxy, C1 - C3-alkyl. Product is synthesized by reaction of the corresponding nucleotide units with 3'- or 5;-terminal phosphorus (+3) or phosphorus (+5)-containing groups and, respectively, with 3'- or 5'-terminal free hydroxy-groups followed by removing the protective groups if necessary. EFFECT: improved method of synthesis. 2 cl, 5 dwg
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