SYNTHESIS OF PHOSPHITYLATED COMPOUNDS USING QUATERNARY HETEROCYCLIC ACTIVATOR Russian patent published in 2012 - IPC C07H21/00 

FIELD: chemistry.

SUBSTANCE: method involves reaction of a hydroxyl-containing compound, which contains a sugar fragment, with a phosphitylation agent in the presence of an activator of formula I , where R = alkyl, cycloalkyl, aryl, aralkyl, heteroalkyl, heteroaryl, R₁, R₂ = either H, or together form a 5-6-member ring, X₁, X₂ = independently N or CH, Y = H or Si(R₄)₃, where R₄ = alkyl, cycloalkyl, aryl, aralkyl, heteroalkyl, heteroaryl, B = trifluoroacetate, dichloroacetate, mesyl, tosyl, o-chlorophenolate.

EFFECT: novel method of producing phosphoramidites.

17 cl, 21 ex