FIELD: organic chemistry, chemical technology. SUBSTANCE: product: L-(-)-2-(aminocarbonyl)-N-(4-amino-2,6-dichlorophenyl)-4-[5,5- -bis-(4-fluorophenyl)-pentyl] -1-piperazine acetamide. Method of synthesis involves cyclization reaction of (-)-(S,S)-N1- N2-bis-(1-phentylethyl)-1,2-ethanediamine with 2,3-dibromopropaneamide. An intermediate compound is hydrogenized, N-alkylated by reductive process and reduced. Agent can be used for heart storage for 24 h in cold cardioplegic solution. EFFECT: improved method of synthesis. 3 cl
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Year |
Author |
Number |
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1988 |
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- Freddi Fransua Vlamink[Be]
- Mark Gustaf Selin Verdonk[Be]
|
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1993 |
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|
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1989 |
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|
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1990 |
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|
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1990 |
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1997 |
- Kukla Majkl Dzhozef
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- Merel' Anri Ehmil' Lodevijk
|
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1991 |
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|
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1990 |
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1990 |
- Al'Fons German Margareta Rajmakers[Be]
- Leopol'D Frans Kornel Ruvens[Be]
- Villi Jokhannes Karolus Van Laroven[Be]
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|
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