FIELD: organic chemistry, nucleotides. SUBSTANCE: product: adenosine monophosphate, yield is 98.0%. Reagent 1: adenosine. Reagent 2: phosphoryl chloride in the presence of triethyl phosphate at ratio 1:1.2:10.4 vol./vol. followed by extraction with a mixture chloroform-water at ratio = 8:11. After upper layer separation 25% ammonia solution is added to this layer to pH = 1.8-1.95, washed with 50% an aqueous ethanol and dried. Synthesized nucleotide is used in medicine as vasodilator agent. EFFECT: improved method of synthesis, increased yield.
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