SUBSTITUTED CYCLOPROPYLAMINO-1,3,5-TRIAZINES, OPTICAL ISOMERS THEREOF, RACENIC MIXTURES OR NON-TOXIC PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF HAVING PHARMACOLOGICAL ACTIVITY, METHOD OF PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION BASED THEREON Russian patent published in 1997 - IPC

FIELD: pharmaceutical industry. SUBSTANCE: present invention describes novel cyclopropylamine-1,3,5- triazines and salts thereof of general formula: wherein R₁ is alkyl, cycloalkyl or alkylcycloalkyl; R₂ is bis (2-methoxyethyl)amino, 3-hydroxy-1-azetidinyl, 3- methoxy-1-acetydinyl, oxo-1-azetidinyl, morpholino, 4- hydroxypiperidino, thiomorpholino-S-oxide-thiomorpholino, S, S-dioxide thiomorpholino, 3-triazolino-S-oxide-3- thiazolidinyl, S,S-dioxide-3-thizolidinyl or 8- oxazabicyclo (3.2.1) oct-3-yl. There compounds are useful for treatment of disorders associated with Altzheimer disease, with senile diseases of Altzheimer type or with any evolutionary pathology for treatment of depression, anxiety, mood disorder, inflammatory processes and asthma. Present invention describes methods of preparation of said compounds by introducing cyclopropylamino or R₂ radical into 1.3.5-triazine ring by forming triazine ring from corresponding N- cyclopropylbiguanide by transformation of radical R₂. Present invention also describes pharmaceutical composition. EFFECT: improved properties of the title compounds. 13 cl, 12 tbl