FIELD: chemistry.
SUBSTANCE: invention relates to compounds of formula 
(I) or pharmaceutically acceptable salts, solvates or tautomers thereof, where substitute M is selected from groups 
D1 and 
D2, having structural formulae given below, and R1, E, A and X are as described in the formula of invention. Disclosed also are pharmaceutical compositions which contain these compounds, methods for synthesis of these compounds, intermediate compounds and synthesis methods thereof, as well as use of compounds of formula (I) in preventing or treating diseases mediated by CDK kinases, GSK-3 kinases or Aurora kinases.
EFFECT: high effectiveness of the compounds.
40 cl, 8 dwg, 18 tbl, 84 ex
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