FIELD: organic chemistry, heterocyclic compounds, pharmacy. SUBSTANCE: invention describes the novel substituted heterocyclic compounds of the formula (I) 
where A means bivalent radical taken among -O-CO-, -CH2-O-CO- and others as indicated in p. 1 of the invention claim; R1 means hydrogen atom or C1-C4-alkyl; m = 2, 3; Ar1 means phenyl possibly substituted with halogen atom, hydroxyl group, C1-C4-alkoxy-group, C1-C4-alkyl, trifluoromethyl group, methylenedihydroxy-group; T means -CH2-Z, -CH(C6H5)2, -C(C6H5)3. Compounds of the formula (I) have affinity to tachikinin receptors, their inhibitory constant Ki is below 10-8 M. Invention describes methods of synthesis of compounds of the formula (I) and intermediate compounds used. Invention describes also the pharmaceutical composition showing antagonistic activity to neurokinin receptors and containing compound of the formula (I) as an active component. EFFECT: new compounds indicated above, improved method of synthesis, valuable pharmacological properties. 25 cl, 3 tbl, 78 ex
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